Hope For the Most Advanced Pancreatic Cancers

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The Skip Viragh Center for Pancreas Cancer Clinical Research and Patient Care attracts the most accomplished young investigators interested in pursuing a career in pancreatic cancer research and treatment. By training with established investigators, Skip Viragh Center fellows are helping advance the science and bringing much-needed new therapies to patients.

Ludwig Johns Hopkins researchers devise new strategy for cancer immunotherapy

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MARCH 1, 2021, NEW YORK – Researchers at the Ludwig Center and Bloomberg-Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center have developed a new strategy for immunotherapy that targets specific genetic alterations commonly associated with cancer to generate a therapeutic immune response. Evaluated in preclinical studies, the strategy employs an antibody technology to target commonly seen alterations in the p53 tumor suppressor gene and cancer-driving RAS gene to stimulate an immune attack on tumors. The studies behind the development of the strategy, led by Ludwig Johns Hopkins investigator Shibin Zhou, its Co-director Bert Vogelstein and their Johns Hopkins colleagues Suman Paul and Sandra Gabelli, are reported in three papers in the current issues of Science Immunology, Science, and Science Translational Medicine.

Pan-Cancer Project

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What is the Pan-Cancer project?
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes project, known as the Pan-Cancer project, is an international collaboration with the aim of identifying common patterns of mutation in more than 2600 whole cancer genomes from the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). It builds upon the previous work of those initiatives, which focused primarily on the regions of the genome that code for proteins.

Pan-Cancer Analysis of Whole Genomes

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Cancer is a disease of the genome, caused by a cell's acquisition of somatic mutations in key cancer genes. These mutations alter pathways involved in regulating cellular growth and interactions with the tissue environment. Until recently, research on the cancer genom

The Contagion Year What we learned about treating COVID-19 in Year One of the pandemic

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This article is part of Harvard Medical School’s continuing coverage of medicine, biomedical research, medical education, and policy related to the SARS-CoV-2 pandemic and the disease COVID-19.

The emergence of SARS-CoV-2 in December of 2019 in China, the microbe ripping across the globe, its uncontrolled spread in the United States …

This dizzying cascade of events overwhelmed hospitals and forced physicians in the trenches to figure out on the fly how to treat a mystifying disease caused by a new virus.


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